วารสารวิจัย มข.
ปีที่ 19 | ฉบับที่ 6plus มกราคม - กุมภาพันธ์ 2558
ชื่อเรื่อง :
-
Title :
Synthesis and Rat Prostate 5-Alpha Reductase Inhibitions of Methylated Quercetin Derivatives
ผู้แต่ง :
-
Authors :
Youngrong Park, Yong-ung Kim and Jaehong Han
บทคัดย่อ :
-
Abstract :
Interested in chemical and biological properties of polymethoxyflavones, a series of methylated quercetin derivatives were synthesized and characterized. Quercetin was methylated with CH 3 I in the presence of K 2 CO 3 /DMF, and the products were purified by column chromatography. Three quercetin derivatives with different methyl group numbers were isolated and the chemical structures were confirmed by IR and NMR. Along with physical characterizations, rat prostate steroid 5?-reductase inhibition of the quercetin derivatives was measured. It was found that methylation of quercetin lowered the inhibitory effect of the derivatives against 5?-reductase.
คำสำคัญ :
-
Keywords :
polymethoxyflavones, quercetin derivatives, steroid 5-alpha reductase